Inhibition of T Cell Proliferation by Macrophage Tryptophan Catabolism
نویسندگان
چکیده
منابع مشابه
Inhibition of T Cell Proliferation by Macrophage Tryptophan Catabolism
We have recently shown that expression of the enzyme indoleamine 2, 3-dioxygenase (IDO) during murine pregnancy is required to prevent rejection of the allogeneic fetus by maternal T cells. In addition to their role in pregnancy, IDO-expressing cells are widely distributed in primary and secondary lymphoid organs. Here we show that monocytes that have differentiated under the influence of macro...
متن کاملPrognostic significance of tryptophan catabolism in adult T-cell leukemia/lymphoma Short title: Tryptophan catabolism in ATL Authors:
Institutions: Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences, Department of Anatomic Pathology and Molecular Diagnostics, Nagoya City University Graduate School of Medical Sciences, Laboratory of Hospital Pharmacy, Nagoya City University Graduate School of Pharmaceutical Sciences,Department of Tumor Immunology, Aichi Medical University School of ...
متن کاملMir-55 inhibition can reduce cell proliferation and induce apoptosis in Jurkat (Acute T cell Leukemia) cell line
Background MicroRNAs are small and non-coding RNA molecules with approximately 22 nt in length that cause inhibition of translation or degradation of mRNA. MiR-155 is a kind of molecule with different functions, such as its role in proliferation, apoptosis, inflammation, differentiation, and immunity. One of its best known functions is apoptosis that affects on caspase-3 activity. The main aim...
متن کاملSuppression of memory CD8 T cell generation and function by tryptophan catabolism.
Dendritic cell-derived indoleamine 2,3-dioxygenase (IDO) suppresses naive T cell proliferation and induces their apoptosis by catalyzing tryptophan, and hence is essential for the maintenance of peripheral tolerance. However, it is not known whether memory T cells are subject to the regulation by IDO-mediated tryptophan catabolism, as memory T cells respond more rapidly and vigorously than thei...
متن کاملInhibition of T cell proliferation by human alveolar macrophages.
The demonstration by Upham et al that human alveolar macrophages selectively inhibit proliferation of T cells by secretion of unidentified eVector molecules raises the question as to whether pathological processes in the lung characterised by extensive macrophage recruitment or activation can have a systemic eVect on T cell development. It has been shown in several studies that patients with pu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1999
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.189.9.1363